Yazar "Ünal, İsmail" için listeleme
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3-Pyridinylboronic acid ameliorates rotenone-induced oxidative stress through Nrf2 target genes in zebrafish embryos
Üstündağ, Fümet Duygu; Ünal, İsmail; Üstündağ, Ünsal Veli; Cansız, Derya; Beler, Merih; Karagöz, Atakan; Kara Subaşat, Hülya; Alturfan, Ahmet Ata; Mega Tiber, Pınar; Emekli Alturfan, Ebru (Springer, 2022)Parkinson's disease (PD) is one of the most common forms of neurodegenerative diseases and research on potential therapeutic agents for PD continues. Rotenone is a neurotoxin that can pass the blood-brain barrier and is ... -
3-Pyridinylboronic acid normalizes the effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in zebrafish embryos
Üstündağ, Fümet Duygu; Ünal, İsmail; Cansız, Derya; Üstündağ, Ünsal Veli; Kara Subaşat, Hülya; Alturfan, Ahmet Ata; Mega Tiber, Pınar; Emekli Alturfan, Ebru (Taylor & Francis Ltd, 2022)1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that damages dopaminergic neurons. Zebrafish has been shown to be a suitable model organism to investigate the molecular pathways in the pathogenesis of ... -
Alcian blue staining for chondrocranium development in zebrafish
Beler, Merih; Ünal, İsmail; Cansız, Derya; Emekli Alturfan, Ebru (Humana Press Inc., 2024)Craniofacial abnormalities are one of the most frequent birth malformations in humans, affecting around one in every thousand live births. The zebrafish (Danio rerio), a model organism that has seen increased usage in ... -
Amelioration of rotenone-induced alterations in energy/redox system, stress response and cytoskeleton proteins by octanoic acid in zebrafish: A proteomic study
Sürmen, Mustafa Gani; Sürmen, Saime; Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Alturfan, Ahmet Ata; Büyükkayhan, Derya; Emekli Alturfan, Ebru (Wiley, 2022)Rotenone is used to generate Parkinson's disease (PD)-like symptoms in experimental animals. Octanoic acid (C8), is the principal fatty acid of medium-chain triglycerides in ketogenic diets. Beneficial effects of ketogenic ... -
Assessment of developmental neurotoxicity using semi-automatic behavior analysis system for zebrafish
Cansız, Derya; Ünal, İsmail; Beler, Merih; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Humana Press Inc., 2024)Traditionally, morphological, conventional, and toxicological approaches have been used to demonstrate neurotoxicity; however, there has been a growing interest in animal behavioral methods for assessing neurotoxicity, ... -
The biocompatibility of a ginger-containing herbal toothpaste on developing zebrafiish embryos
Meşeli, Simge; Üstündağ, Ünsal Veli; Ateş, Perihan Seda; Ünal, İsmail; Işık Alturfan, Ebru (Universitas Indonesia, 2023)The biocompatibility of toothpaste in an oral cavity should be approved by clinical trials. Nowadays, herbal toothpaste is increasing in popularity due to its natural ingredients. Being genetically similar to humans, ... -
The biocompatibility of sodium lauryl sulphate on developing zebrafish embryos
Meşeli, Simge; Kaplan, Gül; Cansız, Derya; Üstündağ, Ünsal Veli; Ünal, İsmail; Emekli Alturfan, Ebru; Yanıkoğlu, Funda; Tağtekin, Dilek (AVES, 2021)Objective: As an anionic surfactant, sodium lauryl sulphate (SLS), is used as an emulsifying agent in toothpastes as well as many different household cleaning products. Many toothpastes contain SLS and it is responsible ... -
Bisphenol a and di(2-ethylhexyl) phthalate exert divergent effects on apoptosis and the Wnt/-catenin pathway in zebrafish embryos: A possible mechanism of endocrine disrupting chemical action
Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş, Perihan Seda; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru (Sage Publications Inc, 2017)Polyethylene terephthalate (PET) and polycarbonate (PC) are the most commonly used plastics in water bottles. Di(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer in PET plastics, and bisphenol A (BPA) is used to ... -
Bisphenol a reveals its obesogenic effects through disrupting glucose tolerance, oxidant–antioxidant balance, and modulating inflammatory cytokines and fibroblast growth factor in zebrafish
Beler, Merih; Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Dandin, Esra; Ak, Esin; Alturfan, A. Ata; Emekli Alturfan, Ebru (SAGE Publications Ltd, 2022)Obesogens affect lipid metabolism, and genetic or epigenetic factors may also contribute to the progression of obesity. Endocrine-disrupting chemicals (EDCs) are the most striking among obesogens. Bisphenol A (BPA) is an ... -
Caprylic acid ameliorates rotenone induced inflammation and oxidative stress in the gut-brain axis in Zebrafish
Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Alturfan, Ahmet Ata; Altınöz, Meriç A.; Elmacı, İlhan; Emekli Alturfan, Ebru (Springer, 2021)Background Dysfunction of the gastrointestinal tract (GIT) is one of the most common non-motor symptom of Parkinson's Disease (PD). Pathological processes causing PD were suggested to initiate in the enteric nervous system ... -
Determination of bisphenol a and phthalate levels in wastewater samples
Akçay, Mansur; Ateş Kalkan, Perihan Seda; Üstündağ, Ünsal Veli; Ünal, İsmail; Cansız, Derya; Emekli Alturfan, Ebru; Alturfan, Ahmet Ata (Istanbul University, 2022)Objective: The use of endocrine-disrupting chemicals (EDCs) such as bisphenol A (BPA) in plastics manufacturing, agriculture, livestock, and paint manufacturing increas daily. The water treated in wastewater treatment ... -
The effect of acetic acid-induced pain in Parkinson's disease model in zebrafish
Cansız, Derya; Ünal, İsmail; Beler, Merih; Üstündağ, Ünsal Veli; Ak, Esin; Emekli Alturfan, Ebru; Alturfan, Ahmet Ata (Elsevier B.V., 2023)Parkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, ... -
The effect of different storage conditions on the migration of chemicals from polyethylene terephthalate and polycarbonate bottles to water
Seyhan, Gümrah; Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş Kalkan, Perihan Seda; Cansız, Derya; Emekli Alturfan, Ebru; Alturfan, Ahmet Ata (Istanbul University, 2022)Objective: Polyethylene terephthalate (PET) and polycarbonate (PC) bottles have been used widely in the last years for the consumption of water and the increased use of these chemicals has raised many concerns regarding ... -
Effects of water samples in polyethylene terephthalate bottles stored at different conditions on zebrafish embryos with relevance to endocrine disrupting chemical migration and adenomatous polyposis coli tumor suppressor gene
Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş, Perihan Seda; Tırpanç, Aybüke; Eğilmezer, Gizem; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli-Alturfan, Ebru (Marmara University, 2019)Objective: Polyethylene terephthalate (PET) is a material that is most commonly used for production of clear plastic bottles. Adenomatous polyposis coli (APC) and beta-catenin have been related with cancer. Aim was to ... -
Endotoxin of porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs
Gündüz, Gizem; Beler, Merih; Ünal, İsmail; Cansız, Derya; Emekli Alturfan, Ebru; Köse, Kemal Naci (Springer, 2023)Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontal diseases, is also associated with hyperglycemia-associated systemic diseases, including diabetes mellitus (DM). Gingipains are the most important ... -
Evaluation of the interaction between proliferation, oxidant-antioxidant status, Wnt pathway, and apoptosis in zebrafish embryos exposed to silver nanoparticles used in textile industry
Eryılmaz, Oğuz; Ateş, Perihan Seda; Ünal, İsmail; Üstündağ, Ünsal Veli; Bay, Sadık; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru; Akalın, Mehmet (Wiley, 2018)Antimicrobial textile products are developing rapidly as an important part of functional textiles. Silver nanoparticles (AgNPs) are nanotechnology products with antimicrobial properties. However, exposure to nanoparticles ... -
Gingipain injection affects intestinal oxidant-antioxidant status and alkaline phosphatase in overfed zebrafish
Gündüz, Gizem; Beler, Merih; Ünal, İsmail; Cansız, Derya; Emekli Alturfan, Ebru; Köse, Kemal Naci (Istanbul University Press, 2023)Objective: Porphyromonas gingivalis (P. gingivalis), a major periodontopathogen, is associated with overfeeding disorders, including metabolic syndrome. Gingipains are one of the most powerful endotoxins of P. gingivalis. ... -
Identification of molecular network of gut-brain axis associated with neuroprotective effects of PPAR delta-ligand erucic acid in rotenone-induced Parkinson's disease model in zebrafish
Ünal, İsmail; Cansız, Derya; Sürmen, Mustafa Gani; Sürmen, Saime; Sezer, Zehra; Beler, Merih; Üstündağ, Ünsal Veli; Güzel, Elif; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Wiley, 2023)Disruption of the gut-brain axis in Parkinson's disease (PD) may lead to motor symptoms and PD pathogenesis. Recently, the neuroprotective potential of different PPAR delta-agonists has been shown. We aimed to reveal the ... -
Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish
Eğimezer, G.; Üstündağ, Ünsal Veli; Ateş, Perihan Seda; Ünal, İsmail; Üstündağ, F. D.; Alturfan, Ahmet Ata; Emekli-Alturfan, Ebru; Adil Altınöz, Meriç; Elmacı, İlhan (SAGE Publications Ltd, 2020)Cancer continues to be a major cause of mortality globally. Zebrafish present suitable models for studying the mechanisms of genotoxic carcinogens. The aim of this study was to investigate the interaction between ... -
Methylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos
Ateş, Perihan Seda; Ünal, İsmail; Üstündağ, Ünsal Veli; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru (Wiley, 2018)Methylparabens (MP) are widely used as preservatives in cosmetics, pharmacy, and food industry. Although acute toxicity studies in animals indicated that parabens are not significantly toxic, the effects of chronic exposure ...